Chapter 8 Structural Biology
Structural biology is The Holy Grail of pharmacology; the dynamic states of pharmacological target activation/inactivation as determined by receptor theory
8.1 Cryogenic electronic microscopy (CryoEM)
The Theoretical and Computational Biophysics Group (TCBG) provides tutorial-based training](https://www.ks.uiuc.edu/Training/Tutorials/)) and a database of software for 3D molecular building,](https://www.ks.uiuc.edu/Development/biosoftdb/biosoft.cgi?&category=3),) dynamics](https://www.ks.uiuc.edu/Development/biosoftdb/biosoft.cgi?&category=2)) and visualization](https://www.ks.uiuc.edu/Development/biosoftdb/biosoft.cgi?&category=1))
Further resources can be found notably at the EMBLI-EBI,](https://www.ebi.ac.uk/training/search-results?query=structural-biology),) Stanford
The NIH established the following CryoEM Centers](https://www.cryoemcenters.org/cryoem-centers/)) through awards](https://www.nih.gov/news-events/news-releases/nih-funds-three-national-cryo-em-service-centers-training-new-microscopists)) to the
National Center for CryoEM Access and Training (NCCAT)](https://nccat.nysbc.org/)) at the New York Structural Biology Center (NYSBC),](https://nysbc.org/),) the
Pacific Northwest Center for Cryo-EM](https://pncc.labworks.org/)) at the Pacific Northwest National Laboratory(PNNL),](https://www.pnnl.gov/),) the
Stanford-SLACC Cryo-EM Center](https://cryoem-s2c2.slac.stanford.edu/)) at the National Accelerator Laboratory](https://www6.slac.stanford.edu/))
**Online learning resources include**:
Thermo Fisher’s EM-Learning](https://em-learning.com/)) and
CryoEM Learning Center](https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences/learning-center.html)) by
Grant Jensen, CalTech,](https://cryo-em-course.caltech.edu/),) and
Matthijn Vos, the Pasteur Institute](https://research.pasteur.fr/en/team/nanoimaging/))
Yale CryoEM,](https://cryoem.yale.edu/cryo-em/workshops-and-online-courses),)
UNC CryoEM Core](https://www.med.unc.edu/cryo-em/)) lists resources available,](https://www.med.unc.edu/cryo-em/cryoem-links-and-resources/),) and
NIGMS National Resource for Automated Molecular Microscopy (NRAMM)](https://nramm.nysbc.org/workshops-and-courses/))